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Functional connectivity change across multiple cortical networks relates to episodic memory changes in aging

Sammendrag

A major task of contemporary cognitive neuroscience of aging is to explain why episodic memory declines. Change in resting-state Functional Connectivity (rsFC) could be a mechanism accounting for reduced function. We addressed this through three studies. In Study 1, 119 healthy participants (20-83 years) were followed for 3.5 years with verbal recall testing and MRI. Independently of atrophy, recall change was related to change in rsFC in anatomically widespread areas. Striking age-effects were observed in that a positive relationship between rsFC and memory characterized older participants while a negative relationship was seen among the younger and middle-aged. This suggests that cognitive consequences of rsFC change are not stable across age. In Study 2 and 3, the age-dependent differences in rsFC-memory relationship were replicated by use of a simulation model (Study 2) and by a cross-sectional experimental recognition memory task (Study 3). In conclusion, memory changes were related to altered rsFC in an age-dependent manner, and future research needs to detail the mechanisms behind age-varying relationships.

Om publikasjonen

Forfattere:

Sneve, Markus H., Håkon Grydeland, Andreas B. Storsve, Ann-Marie G de Lange, Inge K Amlien, Ole J. Røgeberg, Kristine B. Walhovd

År:

2015

Tidsskrift:

Neurobiology of Aging

Serie:

Vitenskapelige tidsskrift

Prosjekt:

Lenke:

[DOI]